Article
Lack of defective expression of the ATM gene in sporadic breast cancer tissues and cell lines.
International journal of oncology - 1 Apr 2000
Kovalev S, Mateen A, Zaika A I, O'Hea B J, Moll U M
Abstract excerpt
Homozygous mutations of the gene mutated in ataxia telangiectasia (ATM) causes the AT syndrome, a pleiotropic phenotype that includes an increased risk of cancer. Most of the known mutations at the ATM gene lead to truncations which are usually associated with instability of mRNA and protein. A decrease or loss of ATM protein expression is associated with specific lymphoid malignancies in AT and non-AT patients....
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