Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reverse gyrase, the two domains intimately cooperate to promote positive supercoiling.

The Journal of biological chemistry - 30 Jun 2000

Déclais A C, Marsault J, Confalonieri F, de La Tour C B, Duguet M

Abstract excerpt

Reverse gyrases are atypical topoisomerases present in hyperthermophiles and are able to positively supercoil a circular DNA. Despite a number of studies, the mechanism by which they perform this peculiar activity is still unclear. Sequence data suggested that reverse gyrases are composed of two putative domains, a helicase-like and a topoisomerase I, usually in a single polypeptide. Based on these predictions,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to DNA, Superhelical
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Topoisomerases, Type II

Share to Oligonucleotides

Share to Silver Staining

Share to Sodium Chloride

Share to Tyrosine

Source

Identifiers

PMID: 10748189
DOI: 10.1074/jbc.M910091199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reverse gyrase, the two domains intimately cooperate to promote positive supercoiling.PMID 10748189Read ↗

The reverse gyrase helicase-like domain is a nucleotide-dependent switch that is attenuated by the topoisomerase domain.Semantic proximity Read ↗

Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) promotes positive supercoiling of DNA by T. maritima reverse gyrase.Semantic proximity Read ↗

Investigating the role of the latch in the positive supercoiling mechanism of reverse gyrase.Semantic proximity Read ↗

Mutational analysis of the helicase-like domain of Thermotoga maritima reverse gyrase.Semantic proximity Read ↗

Functional evaluation of four putative DNA-binding regions in Thermoanaerobacter tengcongensis reverse gyrase.Semantic proximity Read ↗

Topoisomerase activity of the hyperthermophilic replication initiator protein Rep75.Semantic proximity Read ↗

Bacillus subtilis PcrA Helicase Removes Trafficking Barriers.Semantic proximity Read ↗

Analysis of DNA cleavage by reverse gyrase from Sulfolobus shibatae B12.Semantic proximity Read ↗

Modulated control of DNA supercoiling balance by the DNA-wrapping domain of bacterial gyrase.Semantic proximity Read ↗

Biochemical characterization and mutational studies of a thermostable endonuclease III from Sulfolobus islandicus REY15A.Semantic proximity Read ↗

The AddAB helicase-nuclease catalyses rapid and processive DNA unwinding using a single Superfamily 1A motor domain.Semantic proximity Read ↗

DNA Gyrase of Deinococcus radiodurans is characterized as Type II bacterial topoisomerase and its activity is differentially regulated by PprA in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.