Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Topoisomerase activity of the hyperthermophilic replication initiator protein Rep75.

Nucleic acids research - 1 Jun 2000

Marsin S, Marguet E, Forterre P

Abstract excerpt

The plasmid pGT5 from the hyperthermophilic archaeon Pyrococcus abyssi replicates via the rolling circle mechanism. pGT5 encodes the replication initiator protein Rep75 that exhibits a nicking-closing (NC) activity in vitro on single-stranded oligonucleotides containing the pGT5 double-stranded origin (dso) sequence. Some mesophilic Rep proteins present site-specific DNA topo-isomerase-like activity on a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Archaeal Proteins
Share to DNA Ligases
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Superhelical

Share to DNA Topoisomerases, Type I

Share to Nucleic Acid Conformation

Share to Nucleotidyltransferases

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 10871346
DOI: 10.1093/nar/28.11.2251
PMCID: PMC102634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Topoisomerase activity of the hyperthermophilic replication initiator protein Rep75.PMID 10871346Read ↗

Characterization of the ColE2-like replicon of plasmid pTT8 from Thermus thermophilus.Semantic proximity Read ↗

The reverse gyrase helicase-like domain is a nucleotide-dependent switch that is attenuated by the topoisomerase domain.Semantic proximity Read ↗

Single-strand DNA processing: phylogenomics and sequence diversity of a superfamily of potential prokaryotic HuH endonucleases.Semantic proximity Read ↗

Identification of a megaplasmid centromere reveals genetic structural diversity within the repABC family of basic replicons.Semantic proximity Read ↗

A phage mechanism for selective nicking of dUMP-containing DNA.Semantic proximity Read ↗

Molecular analysis and characterization of a broad-host-range plasmid, pEP2.Semantic proximity Read ↗

Geminivirus replication proteins are related to prokaryotic plasmid rolling circle DNA replication initiator proteinsSemantic proximity Read ↗

Functional characterization of the repA replication gene of linear plasmid prophage N15.Semantic proximity Read ↗

DNA Helicase Activity Is Associated with the Replication Initiator Protein Rep of Tomato Yellow Leaf Curl GeminivirusSemantic proximity Read ↗

Investigating the role of the latch in the positive supercoiling mechanism of reverse gyrase.Semantic proximity Read ↗

Reverse gyrase, the two domains intimately cooperate to promote positive supercoiling.Semantic proximity Read ↗

Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA VirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.