Article
High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12.
American journal of human genetics - 1 Jun 2000
Duerr R H, Barmada M M, Zhang L, Pfützer R, Weeks D E
Abstract excerpt
Epidemiological studies have shown that genetic factors contribute to the pathogenesis of the idiopathic inflammatory bowel diseases (IBD), Crohn disease (CD) and ulcerative colitis (UC). Recent genome scans and replication studies have identified replicated linkage between CD and a locus on chromosome 16 (the IBD1 locus), replicated linkage between IBD (especially UC) and a locus on chromosome 12q (the IBD2...
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