Article
The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction.
Inflammatory bowel diseases - 1 Jan 2005
Pierik Marie, Yang Huiying, Barmada Michael M, Cavanaugh Juleen A, Annese Vito, Brant Steven R, Cho Judy H, Duerr Richard H, Hugot Jean-Pierre, McGovern Dermot P, Paavola-Sakki Paulina, Radford-Smith Graham L, Pavli P, Silverberg Mark S, Schreiber Stephan, Taylor Kent D, Vlietinck Robert
Abstract excerpt
BACKGROUND AND AIMS: The inflammatory bowel diseases (IBDs) Crohn's disease (CD) and ulcerative colitis are complex disorders with an important genetic determinant. One gene associated with CD has been identified: NOD2/CARD15. Two independent genome-wide scans found significant evidence (logarithm of odds [LOD] 3.6) and suggestive evidence (LOD 2.8) for linkage on locus 14q11-12, also known as the IBD4 locus. To...
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