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Article

Vascular factors are critical in selective neuronal loss in an animal model of impaired oxidative metabolism.

Journal of neuropathology and experimental neurology - 1 Mar 2000

Calingasan N Y, Huang P L, Chun H S, Fabian A, Gibson G E

Abstract excerpt

Thiamine deficiency (TD) models the cellular and molecular mechanisms by which chronic oxidative deficits lead to death of select neurons in brain. Region- and cell-specific oxidative stress and vascular changes accompany the TD-induced neurodegeneration. The current studies analyzed the role of oxidative stress in initiating these events by testing the role of intercellular adhesion molecule-1 (ICAM-1) and...

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Identifiers

PMID: 10744059
DOI: 10.1093/jnen/59.3.207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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