A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings.

doi:10.1046/j.1469-1809.1998.6210025.x

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Article

A pedigree-based linkage study of coeliac disease: failure to replicate previous positive findings.

Annals of human genetics - 1 Jan 1998

Brett P M, Yiannakou J Y, Morris M A, Bronson S R, Mathew C, Curtis D, Ciclitira P J

Abstract excerpt

Coeliac Disease (CD) is a gluten sensitive enteropathy characterised by villous atrophy and crypt cell hyperplasia. There is a tight HLA association between CD and the HLA DQ alleles DQA1*0501, DQB1*0201 (DQ2), arranged in either cis- or trans- configuration, are found in 98.9% of cases in Northe...

Topics

Celiac Disease
Cohort Studies
Female
Genetic Heterogeneity
Genetic Predisposition to Disease
HLA Antigens
Humans
Lod Score
Male
Microsatellite Repeats
Pedigree

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