Article
Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells.
DNA and cell biology - 1 Feb 2005
Chen Y-F, Shin S-J, Lin S-R
Abstract excerpt
In our previous study on the tumorigenesis of human functional adrenal tumors, we observed a high frequency of point mutation in the K-ras gene in clinical adrenal tumors. Therefore, we analyzed gene profiles of mutant K-ras transfected adrenocortical cells by DNA microarray to determine the expression pattern of genes related to cell cycle, signal transduction, apoptosis, tumorigenesis, steroidogenesis, and...
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