Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol.

Human molecular genetics - 15 May 2004

Knoblauch Hans, Bauerfeind Anja, Toliat Mohammad Reza, Becker Christian, Luganskaja Tatjana, Günther Ulf Peter, Rohde Klaus, Schuster Herbert, Junghans Christine, Luft Friedrich C, Nürnberg Peter, Reich Jens Georg

Abstract excerpt

Single nucleotide polymorphisms (SNPs) and derived haplotypes within multiple genes may explain genetic variance in complex traits; however, this hypothesis has not been rigorously tested. In an earlier study we analyzed six genes and have now expanded this investigation to include 13. We studied 250 families including 1054 individuals and measured lipid phenotypes. We focused on low-density cholesterol (LDL),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to LIPC gene

Share to Genetic Testing

Share to Germany

Share to Haplotypes

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 15044381
DOI: 10.1093/hmg/ddh119

Genes

CETP
LIPC
APOE
LDLR
ABCA1
APOB
LPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol.PMID 15044381Read ↗

Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population.Semantic proximity Read ↗

A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.Semantic proximity Read ↗

Single nucleotide polymorphism haplotypes in the cholesteryl-ester transfer protein (CETP) gene and lipid phenotypes.Semantic proximity Read ↗

Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol.Semantic proximity Read ↗

The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations.Semantic proximity Read ↗

Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels.Semantic proximity Read ↗

The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.Semantic proximity Read ↗

Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans.Semantic proximity Read ↗

Simultaneous assessment of genetic and epigenetic contributions to plasma lipid levels with respect to cardiovascular riskSemantic proximity Read ↗

Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions.Semantic proximity Read ↗

LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.Semantic proximity Read ↗

Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.