Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.

doi:10.1038/sj.onc.1203461

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Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.

Oncogene - 16 Mar 2000

Matsuzaki T, Aisaki K i, Yamamura Y, Noda M, Ikawa Y

Abstract excerpt

The role of Ras and MAP kinases (MAPKs) in the regulation of erythroid differentiation was studied using a cell line (SKT6) derived from Friend virus (Anemic strain)-induced murine erythroleukemia. This cell line undergoes differentiation in vitro in response to erythropoietin (EPO) or other chemical inducers such as dimethylsulfoxide (DMSO). When a constitutively active ras mutant (ras12V) was expressed in SKT6...

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Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.

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Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line.

Abstract excerpt

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