Article
Functional compensation between hematopoietic stem cell clones in vivo.
EMBO reports - 1 Aug 2018
Nguyen Lisa, Wang Zheng, Chowdhury Adnan Y, Chu Elizabeth, Eerdeng Jiya, Jiang Du, Lu Rong
Abstract excerpt
In most organ systems, regeneration is a coordinated effort that involves many stem cells, but little is known about whether and how individual stem cells compensate for the differentiation deficiencies of other stem cells. Functional compensation is critically important during disease progression and treatment. Here, we show how individual hematopoietic stem cell (HSC) clones heterogeneously compensate for the...
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