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Article

Pathology of Hereditary Nonpolyposis Colorectal Cancer

1 Jun 2000

Abstract excerpt

The magnitude of the pathologist's role in the diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) is underestimated. The diagnostic features are not specific to HNPCC cancers, but relate to all cancers showing high levels of DNA microsatellite instability (MSI-H). Three major groups of MSI-H cancers can be recognized by histopathological criteria: (1) right-sided poorly differentiated cancers, (2)...

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PMID: 10911906
DOI: 10.1111/j.1749-6632.2000.tb06701.x

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