Article
Phenotypic changes of the mesangium in diabetic nephropathy.
Journal of diabetes and its complications - 1 Jan 2000
Makino H, Kashihara N, Sugiyama H, Kanao K, Sekikawa T, Shikata K, Nagai R, Ota Z
Abstract excerpt
In diabetic nephropathy there is accumulation of matrix proteins. Overproduction of these matrix proteins considered to be due to the phenotypic change of mesangial cell. In order to detect the phenotypic change of the mesangial cell, renal biopsy specimens from patients with diabetic nephropathy were stained with antibodies against various types of collagens and contractile-associated protein, caldesmon. Type...
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