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Article

Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells.

American journal of physiology. Renal physiology - 1 Oct 2001

Essig M, Terzi F, Burtin M, Friedlander G

Abstract excerpt

The effects of flow-induced mechanical strains on the phenotype of proximal tubular cells were addressed in vivo and in vitro by subjecting LLC-PK(1) and mouse proximal tubular cells to different levels of flow. Laminar flow (1 ml/min) induced a reorganization of the actin cytoskeleton and significantly inhibited the expression of plasminogen activators [tissue-type (tPA) activity: 25% of control cells; tPA mRNA:...

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Source

Identifiers

PMID: 11553522
DOI: 10.1152/ajprenal.2001.281.4.F751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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