Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Apr 2000

Yao W D, Rusch J, Poo M m, Wu C F

Abstract excerpt

We describe a novel bioassay system that uses Xenopus embryonic myocytes (myoballs) to detect the release of acetylcholine from Drosophila CNS neurons. When a voltage-clamped Xenopus myoball was manipulated into contact with cultured Drosophila "giant" neurons, spontaneous synaptic current-like events were registered. These events were observed within seconds after contact and were blocked by curare and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Bungarotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cadmium

Share to Cyclic AMP-Dependent Protein Kinases

Share to Electric Stimulation

Share to Synaptic Transmission

Share to Tetrodotoxin

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 10729343
PMCID: PMC6772254

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations.PMID 10729343Read ↗

cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce.Semantic proximity Read ↗

Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae.Semantic proximity Read ↗

Two independent pathways mediated by cAMP and protein kinase A enhance spontaneous transmitter release at Drosophila neuromuscular junctions.Semantic proximity Read ↗

Regional calcium regulation within cultured Drosophila neurons: effects of altered cAMP metabolism by the learning mutations dunce and rutabaga.Semantic proximity Read ↗

Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release.Semantic proximity Read ↗

Distinct requirements for evoked and spontaneous release of neurotransmitter are revealed by mutations in the Drosophila gene neuronal-synaptobrevin.Semantic proximity Read ↗

Selective effects of neuronal-synaptobrevin mutations on transmitter release evoked by sustained versus transient Ca2+ increases and by cAMP.Semantic proximity Read ↗

Properties of short-term synaptic depression at larval neuromuscular synapses in wild-type and temperature-sensitive paralytic mutants of Drosophila.Semantic proximity Read ↗

Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.Semantic proximity Read ↗

straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.Semantic proximity Read ↗

Central cholinergic synaptic vesicle loading obeys the set-point model in Drosophila.Semantic proximity Read ↗

Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.