Article
Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 May 2021
Yu Szi-Chieh, Liewald Jana F, Shao Jiajie, Steuer Costa Wagner, Gottschalk Alexander
Abstract excerpt
Release of neuropeptides from dense core vesicles (DCVs) is essential for neuromodulation. Compared with the release of small neurotransmitters, much less is known about the mechanisms and proteins contributing to neuropeptide release. By optogenetics, behavioral analysis, electrophysiology, electron microscopy, and live imaging, we show that synapsin SNN-1 is required for cAMP-dependent neuropeptide release in...
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