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Article

Central cholinergic synaptic vesicle loading obeys the set-point model in Drosophila.

Journal of neurophysiology - 1 Feb 2016

Cash Francesca, Vernon Samuel W, Phelan Pauline, Goodchild Jim, Baines Richard A

Abstract excerpt

Experimental evidence shows that neurotransmitter release, from presynaptic terminals, can be regulated by altering transmitter load per synaptic vesicle (SV) and/or through change in the probability of vesicle release. The vesicular acetylcholine transporter (VAChT) loads acetylcholine into SVs at cholinergic synapses. We investigated how the VAChT affects SV content and release frequency at central synapses in...

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PMID: 26655826
DOI: 10.1152/jn.01053.2015

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