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Article

Regional calcium regulation within cultured Drosophila neurons: effects of altered cAMP metabolism by the learning mutations dunce and rutabaga.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2002

Berke Brett, Wu Chun-Fang

Abstract excerpt

The dunce (dnc) and rutabaga (rut) mutations of Drosophila affect a cAMP-dependent phosphodiesterase and a Ca(2+)/CaM-regulated adenylyl cyclase, respectively. These mutations cause deficiencies in several learning paradigms and alter synaptic transmission, growth cone motility, and action potential generation. The cellular phenotypes either are Ca(2+) dependent (neurotransmission and motility) or mediate a...

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PMID: 12040051
PMCID: PMC6758795

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