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Mapping of the POF1 locus and identification of putative genes for premature ovarian failure

1 Apr 2000

Abstract excerpt

We have identified a breakpoint on the X chromosome which is associated with premature ovarian failure (POF). Using polymerase chain reaction (PCR) probes of polymorphic microsatellites and fluorescent in-situ hybridization (FISH), this breakpoint has been narrowed to a region of 300 kb spanned by two P1 artificial chromosomes (PAC). Computer exon prediction and gene homology programs revealed three genes in this...

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PMID: 10729312
DOI: 10.1093/molehr/6.4.314

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