Article
Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B.
Human reproduction (Oxford, England) - 1 Dec 2004
Bione S, Rizzolio F, Sala C, Ricotti R, Goegan M, Manzini M C, Battaglia R, Marozzi A, Vegetti W, Dalprà L, Crosignani P G, Ginelli E, Nappi R, Bernabini S, Bruni V, Torricelli F, Zuffardi O, Toniolo D
Abstract excerpt
BACKGROUND: Balanced X;autosome translocations interrupting the 'critical region' of the long arm of the human X chromosome are often associated with premature ovarian failure (POF). However, the mechanisms leading to X-linked ovarian dysfunction are largely unknown, as the majority of the X chromosome breakpoints have been mapped to gene-free genomic regions. A few genes have been found to be interrupted, but...
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