Article
Genes governing premature ovarian failure.
Reproductive biomedicine online - 1 Jun 2010
Dixit Hridesh, Rao Lakshmi, Padmalatha Venkata, Raseswari Turlapati, Kapu Anil Kumar, Panda Bineet, Murthy Kanakavalli, Tosh Durgadutta, Nallari Pratibha, Deenadayal Mamata, Gupta Nalini, Chakrabarthy Baidyanath, Singh Lalji
Abstract excerpt
Premature ovarian failure (POF) is unexplained amenorrhoea (>6 months), increased FSH (>20 IU/l) and LH occurring before 40 years. Several genes are reported as having significance in POF, including genes governing regulation of the hypothalamic-pituitary-ovarian axis, but their role in ovarian physiology is not known. Deletions or translocations in Xq arm have been found to be associated with POF, assuming...
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