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Article

MDM2-C Functions as an E3 Ubiquitin Ligase

1 Aug 2020

Abstract excerpt

BACKGROUND: Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase that is over-expressed in many cancers and regulates target proteins through ubiquitination. Full-length MDM2 (MDM2-FL) is best known for targeting wild-type p53 for degradation by the proteasome, but the functions of the many splice variants of MDM2 are under-explored. The three well-studied alternative MDM2 isoforms are MDM2-A/ALT2, MDM2-B/ALT1,...

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PMID: 32904724
DOI: 10.2147/cmar.s260943

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