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Article

Procedures for preparing biologically inactive, but immunogenic HIV-1 Tat protein (Tat toxoid) for human use.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Feb 2000

Le Buanec H, Bizzini B

Abstract excerpt

Extracellular Tat can exercise its deleterious effects on cells surrounding HIV-1-infected cells and allow spreading of virus. Extracellular Tat should be neutralized by anti-Tat vaccination using as an immunogen a functionally inactivated but immunogenic Tat preparation (Tat toxoid). In the present paper we show that native Tat can be inactivated without impairment of its immunogenicity by subjecting it to...

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Identifiers

PMID: 10721461
DOI: 10.1016/s0753-3322(00)88639-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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