Article
Reservoir cells no longer detectable after a heterologous SHIV challenge with the synthetic HIV-1 Tat Oyi vaccine.
Retrovirology - 27 Jan 2006
Watkins Jennifer D, Lancelot Sophie, Campbell Grant R, Esquieu Didier, de Mareuil Jean, Opi Sandrine, Annappa Sylvie, Salles Jean-Pierre, Loret Erwann P
Abstract excerpt
BACKGROUND: Extra-cellular roles of Tat might be the main cause of maintenance of HIV-1 infected CD4 T cells or reservoir cells. We developed a synthetic vaccine based on a Tat variant of 101 residues called Tat Oyi, which was identified in HIV infected patients in Africa who did not progress to AIDS. We compared, using rabbits, different adjuvants authorized for human use to test on ELISA the recognition of Tat...
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