Article
Protective role of extracellular superoxide dismutase in hemodialysis patients.
Nephron - 1 Mar 2000
Yamada H, Yamada Y, Adachi T, Fukatsu A, Sakuma M, Futenma A, Kakumu S
Abstract excerpt
BACKGROUND: The superoxide anion and other oxygen radicals have been implicated in the progression of chronic renal failure, and are removed by extracellular superoxide dismutase (EC-SOD) in the extracellular space on the surface of the endothelium. A single-base substitution of the EC-SOD gene which reduces the binding capability to endothelial cells resulting in an increased serum concentration, has been...
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