Article
Role of extracellular superoxide dismutase in patients under maintenance hemodialysis.
Nephron. Clinical practice - 1 Jan 2005
Nakamura Masaaki, Ando Yukio, Sasada Keiko, Haraoka Katsuki, Ueda Mitsuharu, Okabe Hiroaki, Motomiya Yoshihiro
Abstract excerpt
BACKGROUND: It has been well documented that free radical injury is involved in the progression of chronic renal failure. Extracellular superoxide dismutase (EC-SOD), localized on the endothelial cell surface, plays an important role in reducing oxidative stress especially in the vessels by binding to the endothelial cell surface via the heparin-binding domain. Although EC-SOD Arg213Gly, which cannot bind on...
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