A single base change at a splice acceptor site leads to a truncated CAD protein in Urd-A mutant Chinese hamster ovary cells.

doi:10.1007/BF01233449

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A single base change at a splice acceptor site leads to a truncated CAD protein in Urd-A mutant Chinese hamster ovary cells.

Somatic cell and molecular genetics - 1 Jan 1992

Patterson D, Berger R, Bleskan J, Vannais D, Davidson J

Abstract excerpt

We have previously reported the isolation and characterization of mutant Chinese hamster ovary (CHO-K1) cells of the Urd-A complementation group, which require uridine for growth, are deficient in the activities of the first three enzymes of de novo UMP biosynthesis, and produce markedly reduced amounts of a truncated form of the multifunctional protein CAD, which contains these three enzyme activities. We report...

Topics

Amino Acid Sequence
Animals
Aspartate Carbamoyltransferase
Base Sequence
CHO Cells
Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Cricetinae
Cricetulus
Dihydroorotase
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multienzyme Complexes

Mutation

Polymerase Chain Reaction

RNA Splicing

Transcription, Genetic

Uridine

Source

Open in PubMed

Identifiers

PMID: 1347664
DOI: 10.1007/BF01233449

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1347664-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single base change at a splice acceptor site leads to a truncated CAD protein in Urd-A mutant Chinese hamster ovary cells.PMID 1347664Read ↗

Altered splicing of the ATDC message in ataxia telangiectasia group D cells results in the absence of a functional protein.Semantic proximity Read ↗

Molecular characterization of Chinese hamster cells mutants affected in adenosine kinase and showing novel genetic and biochemical characteristics.Semantic proximity Read ↗

Exon recognition and nucleocytoplasmic partitioning determine AMPD1 alternative transcript production.Semantic proximity Read ↗

Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development.Semantic proximity Read ↗

Studies of point mutants define three essential paired nucleotides in the domain 5 substructure of a group II intron.Semantic proximity Read ↗

RNA editing of sorghum mitochondrial atp6 transcripts changes 15 amino acids and generates a carboxy-terminus identical to yeast.Semantic proximity Read ↗

Mutation of putative branchpoint consensus sequences in plant introns reduces splicing efficiency.Semantic proximity Read ↗

Isolation of a human cDNA encoding amidophosphoribosyltransferase and functional complementation of a CHO Ade-A mutant deficient in this activity.Semantic proximity Read ↗

Splicing mutants and their second-site suppressors at the dihydrofolate reductase locus in Chinese hamster ovary cells.Semantic proximity Read ↗

Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis.Semantic proximity Read ↗

Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene.Semantic proximity Read ↗

Characterization of a mutation and an alternative splicing of UDP-galactose transporter in MDCK-RCAr cell line.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.