Article
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy.
Annals of neurology - 1 Mar 2000
Di Maria E, Tabaton M, Vigo T, Abbruzzese G, Bellone E, Donati C, Frasson E, Marchese R, Montagna P, Munoz D G, Pramstaller P P, Zanusso G, Ajmar F, Mandich P
Abstract excerpt
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series of affected subjects was genotyped for a set of genetic markers along the tau protein gene. A specific haplotype is significantly overrepresented in patients versus controls. This haplotype is the same already reported in association with progressive supranuclear palsy. These data...
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