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Article

Activating mutations of TSH receptor.

Annales d'endocrinologie - 1 Feb 2003

Rodien P, Ho S-C, Vlaeminck V, Vassart G, Costagliola S

Abstract excerpt

Mechanisms of activation of G protein-coupled receptor by the agonist, are supposed to rely on release from structural constraints, then allowing the "relaxed" receptor to activate the G protein. By analogy with experimental works on alpha1b adrenergic receptor, showing that mutations could result in constitutive activation of the receptor, it was hypothezised, that similar but spontaneous somatic mutations of...

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Source

Identifiers

PMID: 12707626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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