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Article

Genetic differences in the frequency of the hinge variants of porcine IgA is breed dependent.

Veterinary immunology and immunopathology - 15 Mar 2000

Navarro P, Christenson R K, Ekhardt G, Bosworth B, Lunney J K, Rothschild M, Lemke J, Butler J E

Abstract excerpt

The distribution of the IgA(a) and IgA(b) alleles of porcine IgA in over 160 randomly-selected animals revealed an abundance of heterozygotes but only two b/b homozygotes. Since the IgA(b) allotype is a splice site mutant lacking two-thirds of the hinge, this study tests the hypothesis that pigs with this genotype may be at a selective disadvantage while heterozygous individuals may be at some advantage. This...

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PMID: 10713341
DOI: 10.1016/s0165-2427(00)00150-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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