Article
Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33.
American journal of respiratory and critical care medicine - 1 Mar 2000
Deng Z, Haghighi F, Helleby L, Vanterpool K, Horn E M, Barst R J, Hodge S E, Morse J H, Knowles J A
Abstract excerpt
Familial primary pulmonary hypertension (PPH) is a rare autosomal dominant disease characterized by distinctive changes in pulmonary arterioles that lead to increased pulmonary artery pressures, right ventricular failure, and death. Our previous studies had mapped the disease locus, PPH1, to a 27-cM region on chromosome 2q31-q33, with a maximum multipoint logarithm of the odds favoring genetic linkage score of...
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