Article
A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.
Genomics - 1 Sept 2000
Machado R D, Pauciulo M W, Fretwell N, Veal C, Thomson J R, Vilariño Güell C, Aldred M, Brannon C A, Trembath R C, Nichols W C
Abstract excerpt
Primary pulmonary hypertension (PPH), an often fatal disorder, is characterized by sustained elevation of pulmonary artery pressure of unknown cause. In its familial form (FPPH), the disorder segregates as an autosomal dominant and displays markedly reduced penetrance. A gene for FPPH was previously localized to a 25-cM interval on the long arm of chromosome 2 (2q31-q33). We now report a complete yeast artificial...
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