Article
Primary pulmonary hypertension may be a heterogeneous disease with a second locus on chromosome 2q31.
Journal of the American College of Cardiology - 18 Jun 2003
Rindermann Matthias, Grünig Ekkehard, von Hippel Albrecht, Koehler Rolf, Miltenberger-Miltenyi Gabriel, Mereles Derliz, Arnold Karlin, Pauciulo Michael, Nichols William, Olschewski Horst, Hoeper Marius M, Winkler Jörg, Katus Hugo A, Kübler Wolfgang, Bartram Claus R, Janssen Bart
Abstract excerpt
OBJECTIVES: The aim of our study was to identify genetic causes of primary pulmonary hypertension (PPH), to estimate the proportion of families with mutations in the BMPR2 (bone morphogenetic protein receptor type 2) gene, and to examine whether genetic heterogeneity might play a role. BACKGROUND: The BMPR2 mutations have been identified in a substantial portion of patients with familial or sporadic PPH. However,...
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