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Article

Biased estimation of the recombination fraction using half-sib families and informative offspring.

Genetics - 1 Mar 2001

Gomez-Raya L

Abstract excerpt

A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampling variance can be increased or reduced up to fivefold due to the bias in estimating the recombination fraction and...

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Identifiers

PMID: 11238420
DOI: 10.1093/genetics/157.3.1357
PMCID: PMC1461567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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