Article
Ray38p, a homolog of a purine motif triple-helical DNA-binding protein, Stm1p, is a ribosome-associated protein and dissociated from ribosomes prior to the induction of cycloheximide resistance in Candida maltosa.
Biochemical and biophysical research communications - 1 Jun 2001
Takaku H, Mutoh E, Horiuchi H, Ohta A, Takagi M
Abstract excerpt
Cycloheximide (CYH) resistance in Candida maltosa is dependent on the induction of a ribosomal protein, Q-type L41, the 56th residue of which is glutamine, not proline as in ordinary P-type L41. We found that a 38-kDa protein in a wild-type C. maltosa ribosomal fraction became undetectable upon CYH treatment but detectable again with the establishment of CYH resistance by the induction of Q-type L41. We cloned a...
Topics
- Amino Acid Motifs
- Amino Acid Substitution
- Base Sequence
- Candida
- Cell Division
- Cycloheximide
- Eukaryotic Initiation Factors
- Fungal Proteins
- Molecular Sequence Data
- Molecular Weight
- Mutation
- Peptide Initiation Factors