Article
Expansion of the functional genomics GRACE library reveals genes relevant for temperature-dependent fitness in Candida albicans.
PLoS biology - 1 Oct 2025
Fu Ci, Xiong Emily H, Kupczok Livia, Archambault Linda S, Wang Timothy R W, Holleran Caitlin, Carruthers-Lay Duncan, Zhuang Ting Xuan, Marcoccia Sofia, Zhang Haoyang, Chen Kevin, Anderson Daniel, Yiu Bonnie, Liu Zhongle, Herzel Lydia, Robbins Nicole, Cowen Leah E
Abstract excerpt
A small percentage of species in the fungal kingdom can cause devastating infections in humans, with Candida albicans reigning as a leading cause of systemic disease. One of the key virulence phenotypes for pathogenic fungi is the ability to survive at host body temperature; however, a comprehensive understanding of the mechanisms that orchestrate thermal adaptation in fungi remains incomplete. In this study, we...
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