Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring Viral Interference Using Peptides: Molecular Determinants of HIV-1 Inhibition by a Peptide Derived from Human Pegivirus-1 Envelope Protein E2.

ChemMedChem - 20 Apr 2021

Hoffmann Rebecca, Ruegamer Tamara, Schaubächer Johanna, Rohrhofer Anette, Kirmeß Peter, Fiebig Karen M, Schmidt Barbara, Eichler Jutta

Abstract excerpt

Co-infection with the human pegivirus 1 (HPgV-1) often has a beneficial effect on disease progression in HIV-1-infected individuals. Several HPgV-1 proteins and peptides, including a 20-mer peptide (P6-2) derived from the N-terminal region of the HPgV-1 surface protein E2, have been associated with this phenomenon, which is referred to as viral interference. We identified the cysteine residues, the hydrophobic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to GB virus C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to Peptide Fragments

Share to Protein Binding

Share to Viral Interference

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33378104
DOI: 10.1002/cmdc.202000892
PMCID: PMC8248410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring Viral Interference Using Peptides: Molecular Determinants of HIV-1 Inhibition by a Peptide Derived from Human Pegivirus-1 Envelope Protein E2.PMID 33378104Read ↗

Inhibition of Viral Membrane Fusion by Peptides and Approaches to Peptide DesignSemantic proximity Read ↗

Protein Design of an HIV-1 Entry InhibitorSemantic proximity Read ↗

Rationally Designed Anti-HIV Peptides Containing Multifunctional Domains as Molecule Probes for Studying the Mechanisms of Action of the First and Second Generation HIV Fusion InhibitorsSemantic proximity Read ↗

Peptide-Based Inhibitors of the HIV Envelope Protein and Other Class I Viral Fusion ProteinsSemantic proximity Read ↗

Blocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide.Semantic proximity Read ↗

Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection.Semantic proximity Read ↗

Research strategies of the N-peptide fusion inhibitor: a promising direction for discovering novel antiviralsSemantic proximity Read ↗

Virus‐cell and cell‐cell fusion mediated by the HIV‐1 envelope glycoprotein is inhibited by short gp41 N‐terminal membrane‐anchored peptides lacking the critical pocket domainSemantic proximity Read ↗

Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil.Semantic proximity Read ↗

HIV gp41 C-terminal Heptad Repeat Contains Multifunctional DomainsSemantic proximity Read ↗

Peptide and Non-peptide HIV Fusion InhibitorsSemantic proximity Read ↗

Membrane Interface-Interacting Sequences within the Ectodomain of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Putative Role during Viral FusionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.