Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1.

doi:10.1128/JVI.00257-07

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Article

Unique mutational patterns in the envelope alpha 2 amphipathic helix and acquisition of length in gp120 hypervariable domains are associated with resistance to autologous neutralization of subtype C human immunodeficiency virus type 1.

Journal of virology - 1 Jun 2007

Rong Rong, Gnanakaran S, Decker Julie M, Bibollet-Ruche Frederic, Taylor Jesse, Sfakianos Jeffrey N, Mokili John L, Muldoon Mark, Mulenga Joseph, Allen Susan, Hahn Beatrice H, Shaw George M, Blackwell Jerry L, Korber Bette T, Hunter Eric, Derdeyn Cynthia A

Abstract excerpt

Autologous neutralizing antibodies (NAb) against human immunodeficiency virus type 1 generate viral escape variants; however, the mechanisms of escape are not clearly defined. In a previous study, we determined the susceptibilities of 48 donor and 25 recipient envelope (Env) glycoproteins from five subtype C heterosexual transmission pairs to NAb in donor plasma by using a virus pseudotyping assay, thereby...

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Identifiers

PMID: 17360739
DOI: 10.1128/JVI.00257-07
PMCID: PMC1900276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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