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Article

A neurofibromatosis-1-regulated pathway is required for learning in Drosophila.

Nature - 24 Feb 2000

Guo H F, Tong J, Hannan F, Luo L, Zhong Y

Abstract excerpt

The tumour-suppressor gene Neurofibromatosis 1 (Nf1) encodes a Ras-specific GTPase activating protein (Ras-GAP). In addition to being involved in tumour formation, NF1 has been reported to cause learning defects in humans and Nf1 knockout mice. However, it remains to be determined whether the observed learning defect is secondary to abnormal development. The Drosophila NF1 protein is highly conserved, showing 60%...

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Identifiers

PMID: 10706287
DOI: 10.1038/35002593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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