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Article

Distinct functional domains of neurofibromatosis type 1 regulate immediate versus long-term memory formation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jun 2007

Ho Ivan Shun, Hannan Frances, Guo Hui-Fu, Hakker Inessa, Zhong Yi

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a dominant genetic disorder that causes tumors of the peripheral nervous system. In addition, >40% of afflicted children have learning difficulties. The NF1 protein contains a highly conserved GTPase-activating protein domain that inhibits Ras activity, and the C-terminal region regulates cAMP levels via G-protein-dependent activation of adenylyl cyclase. Behavioral analysis...

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Identifiers

PMID: 17581973
DOI: 10.1523/JNEUROSCI.0933-07.2007
PMCID: PMC6672704

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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