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Article

Neurofibromin regulates G protein-stimulated adenylyl cyclase activity.

Nature neuroscience - 1 Feb 2002

Tong Jiayuan, Hannan Frances, Zhu Yinghua, Bernards Andre, Zhong Yi

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a dominant genetic disorder characterized by multiple benign and malignant nervous system tumors, and by learning defects in 45% of children with NF1 mutations. Studies of neurofibromin, the protein encoded by NF1, have focused on its functions in tumorigenesis and regulation of Ras activity; however, Drosophila NF1 regulates both Ras and cyclic AMP (cAMP) pathways. Expression of...

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PMID: 11788835
DOI: 10.1038/nn792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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