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Article

Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides.

Science (New York, N.Y.) - 2 May 1997

Guo H F, The I, Hannan F, Bernards A, Zhong Y

Abstract excerpt

The human neurofibromatosis type 1 (NF1) tumor suppressor protein functions as a Ras-specific guanosine triphosphatase-activating protein, but the identity of Ras- mediated pathways modulated by NF1 remains unknown. A study of Drosophila NF1 mutants revealed that NF1 is essential for the cellular response to the neuropeptide PACAP38 (pituitary adenylyl cyclase-activating polypeptide) at the neuromuscular...

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Identifiers

PMID: 9115204
DOI: 10.1126/science.276.5313.795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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