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Article

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

1 Feb 2000

Abstract excerpt

Bone morphogenetic protein-4 (BMP4), a member of the transforming growth factor-beta (TGF-beta) family, regulates several developmental processes during animal development. We have now studied the effects of BMP-4 in the metanephric kidney differentiation by using organ culture technique. Human recombinant BMP-4 diminishes the number of ureteric branches and changes the branching pattern. Our data suggest that...

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PMID: 10706139
DOI: 10.1002/(sici)1097-0177(200002)217:2<146::aid-dvdy2>3.0.co;2-i

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