Article
The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects.
American journal of physiology. Renal physiology - 1 Nov 2009
Shah Mita M, Tee James B, Meyer Tobias, Meyer-Schwesinger Catherine, Choi Yohan, Sweeney Derina E, Gallegos Thomas F, Johkura Kohei, Rosines Eran, Kouznetsova Valentina, Rose David W, Bush Kevin T, Sakurai Hiroyuki, Nigam Sanjay K
Abstract excerpt
Kidney organogenesis depends on reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM) to form the UB-derived collecting system and MM-derived nephron. With the advent of in vitro systems, it is clear that UB branching can occur independently of MM contact; however, little has been done to detail the role of MM cellular contact in this process. Here, a model system in which the...
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