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Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases

1 Jan 2016

Abstract excerpt

The gene encoding bone morphogenetic protein-7 (Bmp7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of Bmp7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to...

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PMID: 27679685
DOI: 10.4252/wjsc.v8.i9.288

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