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Article

A novel SMAD4 gene mutation in seminoma germ cell tumors.

Cancer research - 15 Feb 2000

Bouras M, Tabone E, Bertholon J, Sommer P, Bouvier R, Droz J P, Benahmed M

Abstract excerpt

Transforming growth factor (TGF)-beta is known as an antiproliferative factor in the majority of mammalian cells, including stem germ cells. Lack of TGF-beta-induced growth inhibition has been associated with disruptions of TGF-beta receptors and SMADs. In the present study, we performed a mutational analysis of the TGF-beta signaling system, including TGF-beta receptor type I and type II and SMADs (SMAD1-SMAD7),...

Read the complete abstract on PubMed

Topics

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Share to Immunohistochemistry
Share to Polymorphism, Single-Stranded Conformational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Seminoma

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Source

Identifiers

PMID: 10706106

Genes

SMAD4
SMAD1
SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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