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Article

Growth regulatory factors and signalling proteins in testicular germ cell tumours

1 Jan 2003

Abstract excerpt

The molecular basis of testicular germ cell tumourigenesis are not well elucidated. Growth factors regulate cell growth, differentiation and apoptosis. Major families of growth factors are present in the male gonad from early fetal development to adult life. They are involved in germ cell proliferation and differentiation. Growth signalling pathways suffer deregulation in many human malignancies. Given the...

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PMID: 12752264
DOI: 10.1034/j.1600-0463.2003.11101251.x

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