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TCam‐2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF‐beta ligands and retinoic acid

13 Jun 2011

Abstract excerpt

Germ cell testicular cancer is understood to arise during embryogenesis, based on the persistence of embryonic germ cell markers in carcinoma in situ and seminoma. In this study, we examine the potential of the seminoma-derived TCam-2 cell line to be used as representative in functional analyses of seminoma. We demonstrate expression of several early germ cell markers, including BLIMP1, OCT3/4, AP2γ, NANOG and...

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PMID: 21668453
DOI: 10.1111/j.1365-2605.2011.01170.x

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