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Article

TGF‐β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam‐2 into a cell type resembling mixed non‐seminoma

8 Jun 2011

Abstract excerpt

Malignant germ-cell tumours arise from a neoplastic precursor, the carcinoma in situ, and develop into seminomas and/or non-seminomas (embryonal carcinomas, teratomas, yolk-sac tumours and choriocarcinomas). Based on histological and clinical findings, it has been postulated that seminomas can eventually transform into non-seminomas. Here, we used the cell line TCam-2 as model for seminomas and interrogated their...

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PMID: 21649665
DOI: 10.1111/j.1365-2605.2011.01172.x

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