Increased binding of fibrinogen to glycoprotein IIIa-proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease.

doi:10.1053/euhj.1998.1203

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Article

Increased binding of fibrinogen to glycoprotein IIIa-proline33 (HPA-1b, PlA2, Zwb) positive platelets in patients with cardiovascular disease.

European heart journal - 1 May 1999

Goodall A H, Curzen N, Panesar M, Hurd C, Knight C J, Ouwehand W H, Fox K M

Abstract excerpt

AIMS: The GPIIb-IIIa complex on the platelet membrane plays an important part in thrombosis as it is the receptor for fibrinogen. The gene for platelet membrane glyco-protein IIIa has multiple alleles one of which, the GPIIIa-Proline33 (HPA-1b, PlA2, Zwb) allele has been reported in some, but not all studies, to be associated with an increased risk of myocardial infarction. We investigated whether the presence of...

Topics

Aged
Alleles
Angina Pectoris
Blood Platelets
DNA
Female
Fibrinogen
Flow Cytometry
Humans
Male
Middle Aged
Platelet Glycoprotein GPIIb-IIIa Complex
Polymorphism, Genetic
Proline
Protein Binding

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Open in PubMed

Identifiers

PMID: 10329065
DOI: 10.1053/euhj.1998.1203

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